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West Africans Have Cancer-Fighting Genes Inherited From an Unknown Human Ancestor

Evidence of a previously unknown species of human ancestor has been discovered in the DNA of West Africans.

The discovery was made by experts who examined the human genome for out-of-place strings of genetic information.

This revealed the inheritance of markers from an unidentified human-like species, some of which may be beneficial to their descendants, including one that inhibits tumor development.

Researchers believe Homo heidelbergensis, an ancient species of hominin, is the most likely candidate for the ‘ghost’ species.

Arun Durvasula and Sriram Sankararaman of the University of California, Los Angeles, made the discovery. They developed a statistical method for detecting abnormal genetic code without the need for the genome of the species from which it was inherited. This eliminates the need for DNA extracted from extinct African hominins as a comparison point.

Unlike samples of human-like Neanderthals and Densiovans discovered in Europe and Asia, the hotter and wetter climate on the African continent tends to destroy any preserved DNA.

The statistical technique was used on the DNA of 50 modern Yoruba people whose genetic information was sequenced as part of the 1,000 Genomes Project.

This established that approximately 8% of their DNA comes from a previously unknown ‘ghost’ species.

Yoruba-people

While Homo sapiens may be the only hominin species alive today, the planet was home to a variety of human and protohuman species tens of thousands of years ago. Some of these species’ DNA has been passed down to modern humans as a result of interspecies breeding.

Traces of Neanderthal DNA can still be found in people of non-African descent, and Denisovan DNA can still be found in people of Asian ancestry. In 2016, researchers discovered that the DNA of an unknown population of archaic hominins is still present in Pacific Island peoples.

The Neanderthals and Denisovans have been ruled out because their DNA has already been discovered and there is no evidence that they lived in Africa. Many studies show that the closer we get to Africa, the lower the concentration of Neanderthals and Denisovan DNA. Africans have almost no ancestors who were  Neanderthals or Denisovan. Especially West, central and southern Africans.

WHAT DO WE KNOW ABOUT HOMO HEIDELBERGENSIS, THE HUMAN ANCESTOR SPECIES?

Between 600,000 and 200,000 years ago, Homo heidelbergensis roamed Africa, Europe, and Western Asia.

It was an early human ancestor that died out long before modern humans migrated from Africa to Eurasia.

The ancestors of modern humans diverged from a lineage that gave rise to Neanderthals and Denisovans hundreds of thousands of years ago.

According to research published in August 2017 by scientists from the University of Utah, Neanderthals and Denisovans diverged around 744,000 years ago – roughly 300,000 years earlier than previously thought.

This suggests that Homo heidelbergensis came before Neanderthal.

Previously, researchers hypothesized that between 400,000 and 300,000 years ago, a group of heidelbergensis migrated into Europe and West Asia via previously unknown routes, eventually mutating into Neanderthals.

Due to the scarcity of fossil records, scientists have been baffled by the evolutionary tree of Homo heidelbergensis.

Because of the similarities between Neanderthal, Homo heidelbergensis, and Homo sapiens fossils, scientists previously assumed that heidelbergensis fossils were simply variants of Homo sapiens.

Experts made the fining thanks to a statistical method which is able to highlight abnormal genetic code without needing the genome of the species it was inherited from. This established that 8% of Yoruba DNA comes from a yet unknown ‘ghost’ species

article-site-Neanderthal-label

Modern-day pygmies, who may have interbred with the Yoruba people, have also been excluded from the process because their DNA has been sequenced and found to be unrelated.

Homo naledi, a small-brained hominin found roaming the South African plains 250,000 years ago, is a possible but unlikely contender.

Researchers believe they were genetically too different from us to successfully mate and reproduce. “I’d be amazed if there was anything of them in us,” said Mark Thomas of University College London, who was not involved in the study.

A more likely candidate is Homo heidelbergensis, a more advanced hominin that lived in Africa around 200,000 years ago.

It’s also possible that the mysterious DNA came from an isolated group of Homo sapiens or a population of hominins that researchers have yet to discover.

Whatever the answer is, Professor Thomas told New Scientist that the study serves as a reminder that our species did not evolve from a single founding population.

The study’s full results are available in a paper published in the online print repository bioRxiv.

TIMELINE OF HUMAN EVOLUTION

The timeline of human evolution can be traced back millions of years. Experts estimate that the family tree goes as such:

55 million years ago – First primitive primates evolve

15 million years ago – Hominidae (great apes) evolve from the ancestors of the gibbon

7 million years ago – First gorillas evolve. Later, chimp and human lineages diverge

5.5 million years ago – Ardipithecus, early ‘proto-human’ shares traits with chimps and gorillas

4 million years ago – Ape like early humans, the Australopithecines appeared. They had brains no larger than a chimpanzee’s but other more human like features 

3.9-2.9 million years ago – Australoipithecus afarensis lived in Africa.  

2.7 million years ago – Paranthropus, lived in woods and had massive jaws for chewing  

2.6 million years ago – Hand axes become the first major technological innovation 

2.3 million years ago – Homo habilis first thought to have appeared in Africa

1.85 million years ago – First ‘modern’ hand emerges 

1.8 million years ago – Homo ergaster begins to appear in fossil record 

800,000 years ago – Early humans control fire and create hearths. Brain size increases rapidly

400,000 years ago – Neanderthals first begin to appear and spread across Europe and Asia

300,000 to 200,000 years ago – Homo sapiens – modern humans – appear in Africa

54,000 to 40,000 years ago – Modern humans reach Europe 

 
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